I used to do acid when I was younger so tripping never scared me. I would be a poster child for this drug if I could.”, Spravato (esketamine) for Depression: “Been on 84mg for over a year. I definitely don’t recommend that for any of you and hope you have better success. BOTTOMLINE: WHEN IT COMES TO MENTAL HEALTH, NEVER TAKE THE ADVICE OF ONLINE REVIEWS.”, Spravato (esketamine) for Depression: “Hi, My depression now seems worse than ever and my anxiety is at a high level. It’s kind of a last ditch effort so I’m still hopeful.”, Spravato (esketamine) for Depression: “After being on 6 different anti depressants and doing 6 weeks of TMS with no relief from my depression I was prescribed Spravato. Dose: 84mg I’ve had 2 experiences of disassociation, which were extremely pleasant, controllable and very mild, at best. I started to cry and then boom: sobbing, no idea who I was, where I was, visual disturbance so couldn't see correctly, was paranoid, untrusting - I have never been so terrified in all my life. The drug is a nasal spray called esketamine, derived from ketamine—an anesthetic that has made waves for its surprising antidepressant effect. I've used Ketamine once prior to Spravato and that was the best I've felt in 45 years.”, Spravato (esketamine): “An exciting experience that lifts you into a different way of looking at many things. Yesterday was the 3rd treatment of 84mg. The day of the treatment I felt great, but then it seemed to just go away. I want a cure, not games.”, Spravato (esketamine) for Depression: “Spravto But why does it have to be IV? IV ketamine has years of use and they know it works, but because there is zero money to be made they will never approve it so our insurance will pay for it”, Spravato (esketamine): “I had my first experience with Spravato yesterday and the side effects were just awful. I couldn’t feel my face, couldn’t speak, couldn’t breathe, the room was spinning, music felt far away even though I had headphones in. I’ve tried different meds and none have seemed to help. I spent one week totally alone I saw nobody except for my ride and my time in treatment. Then you’re in for a ride of feeling like you’re outside your body. I began week 1 with 2 treatments( required 2 treatments every week for first 4 weeks). A panoply of medicines, always with Cylert or Ritalin, provided a substantial modicum of relief for decades. My physician has recommended that I start Spravato, as he has sometimes seen its benefits last longer. A compound called phencyclidine was initially created, and in early animal studies it demonstrated defiantly unusual effects. I had to find this out on my own, the Drs don't tell you much about what and what not to do when you take this medication. While I chose MDD as the condition, I am more accurately Treatment Resistant Depression.”, Spravato (esketamine) for Depression: “Spravato has been miraculous for me. The day after my third treatment (first at 84 mg) I felt the darkness lifting. Esketamine has an average rating of 5.2 out of 10 from a total of 39 ratings for the treatment of Depression. I had 15 ketamine injections a year ago and they helped a little. The one way that these minerals can enter the human overall body is from the intake of fruits, veggies, and fungi which take up them by using the soil wherein they are developed. The FDA has, as of March 6th this year (2019), approved esketamine for use in treating depression. I don’t dread my life anymore. Using ketamine or esketamine to treat depression is not a breakthrough discovery. It works best for me about 48 hours after a visit. As far as the treatments themselves I get a feeling of euphoria for the first 40 minutes. Note: When the cost is Ketamine infusions hits 200$ I'm going to switch. Prior to starting treatments, I had been sleeping 16+ hours a day and had little motivation to accomplish even basic self-care. Yes, the 2 hours during treatment can be a bit "trippy"and uncomfortable, and I agree with other posters, surround yourself with comforting, soothing things. Ketamine infusions worked well, that is until I developed severe UTI’s, kidney stones and a PSA level of 9.8! Not a cure. I felt a lightening of my mood after the first three treatments, however the feeling didn’t last long maybe 24 hours. BOTTOMLINE: WHEN IT COMES TO MENTAL HEALTH, NEVER TAKE THE ADVICE OF ONLINE REVIEWS.”, Spravato (esketamine): “Hi, I did start having increased anxiety, often very anxious when waking in the morning. I don’t feel 100% back to normal today (appointment was yesterday). Esketamine is fast acting, showing improvement in depression symptoms in patients in as little as 24 hours after the first dose. 33% of those users who reviewed Esketamine reported a positive effect, while 33% reported a negative effect. I definitely don’t recommend that for any of you and hope you have better success. The nasal spray drips down your throat and tastes terrible. Researchers at Mayo Clinic's campus in Rochester, Minnesota, have demonstrated that continuation-phase administration of ketamine at weekly intervals to patients with treatment-resistant depression who remitted during acute-phase ketamine treatment can extend the duration of … While on it I had increased suicidal ideations. My suicidal thoughts have lessoned by half. So far, no depression reduction, which saddens me, and I'm scared to have another trip like I did yesterday.”, Spravato (esketamine): “I suffer from depression. It gave me a headache. I have now had 2 treatments with 53 mg. It does not assist anxiety. My experiences are all over the place. I am 36, and have had depression since I was 12. Having bipolar disorder, I am hypervigilant about not getting manic and so far no manic episodes, just healthy increased energy. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. 28% of those users who reviewed Esketamine reported a positive effect, while 38% reported a negative effect. I hate the whole experience. What I am nervous about is the efficacy of this because to have to go once a week is very expensive... good luck to everyone there is hope!!!! I’ve yet to have an infusion. I had to find this out on my own, the Drs don't tell you much about what and what not to do when you take this medication. Spravato is a waste of time and money. It took about six weeks and I've also been taking Prozac and some supplements which have also helped. It also causes me to have a strong urge to urinate and messes with my sense of taste. I hope this helps someone else.”, Spravato (esketamine): “Details: a medium intranasal dose twice a week in office for a month, followed by a high dose once a week. If you stop, your depression will return. For me, the first 20 minutes are unpleasant, like a psychadelic trip that is a bit too strong. I heard of Spravato and was very excited to know there was a treatment out there that could work. If you can’t stand - ask for help. I found that putting your head between your legs after you inject until it soaks in really amplifies the effects. Was on 56mg 2x week for a month (eventually I had no immediate reaction as my body got used to the drug - lingering tiredness, so I did the treatments in the late afternoon) and have had 3 treatments with 84mg. However the doctor charged $300 per visit which was not covered by my insurance. The doctor and staff were great and supportive. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Felt hungover. Due to my improved condition, I am currently enrolled in three online courses which I am thoroughly enjoying - this would not have been fathomable just three short months ago. Diagnosis: MDD & CPTSD The night of the treatment, I feel exhausted and this is lasting into the following day. It is a huge experience for anyone wanting to try it but if you're at wits end, I'd say go for it. Yes, the 2 hours during treatment can be a bit "trippy"and uncomfortable, and I agree with other posters, surround yourself with comforting, soothing things. I was crying for my mom. Mixed results so far but I have hope. FDA Approval of Esketamine. I feel lethargic- spacey with no appetite. What is clear is that it is fast-acting. Oral vs. Intramuscular vs. Intranasal Ketamine: Why Route Matters Estelle Autissier, RN At Principium Psychiatry, we offer our patients cutting-edge treatment options for their depression, and one of our main stars is IV (intravenous) ketamine. This drug was barely vetted by the FDA with only 80 test subjects in their group. Listen to soft music, wear comfortable clothes or watch uplifting videos.”, Spravato (esketamine) for Depression: “On Spravato I felt like I was going to die. An efficient asymmetric synthesis of (S)-ketamine (esketamine) based on catalytic enantioselective transfer hydrogenation of cyclic enone and [3,3]-sigmatropic rearrangement of allylic cyanate to isocyanate is described. Everyone is different. I hate the whole experience. I enjoyed the experience, however it did absolutely nothing to help my depression. Let’s just say this is when you have tried everything else and you still need help. I heard of Spravato and was very excited to know there was a treatment out there that could work. Everyone is different with this treatment don't think its going to be fun cuz its not. for the first time in my life I feel like I can function normally. This information is NOT intended to endorse any particular medication. It felt like my legs were separated from my body. Esketamine, sold under the brand name Spravato among others, is a medication used as a general anesthetic and for treatment-resistant depression. I went up to the 84mg dose on the 4th trip. Within hours, people may experience changes to the brain that reduce symptoms of depression. If you can stand go to the bathroom if you have to. As you inhale the Spravato you get the nasty taste. I highly suggest you have a strong support system in place beforehand because you will need it. Feeling like you’re completely numb. I only got to the 2nd spray before I had to spray the other into the trash to act like I used it cause they refused to believe I had ODED. I have vomited on the higher dose, but an accompanying zofran has helped tremendously. But after that I elected to stop taking Spravato. My depression score went from severe depression to mild mood disturbance. This has led to three rounds of research over the past several years, the third being completed recently. I am hoping with the few more sessions I will keep on improving. It is much milder, less intense, and effective in my view based on my response. This information is NOT intended to endorse any particular medication. Spravato is for depression only. Good luck!”, Spravato (esketamine) for Depression: “I’ve had 5 Spravato treatments so far for depression. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Due to my improved condition, I am currently enrolled in three online courses which I am thoroughly enjoying - this would not have been fathomable just three short months ago. I do not recommend you bring a family member while the medication is working. I don’t have a strong reaction to the medication when it’s administered, just a slight disassociation with time and place that I can easily bring into perspective. If others try Spravato, I hope you have better results. Setting aside issues of health care economics and FDA procedures, esketamine also represents the first psychedelic treatment approved by the FDA for a psychiatric condition. It took 4 minutes to kick in. I do not in any ways feel cured but I do feel a little better. Please don’t try this unless it’s your LAST resort.”, Spravato (esketamine) for Major Depressive Disorder: “Had my first Spravato treatment today. Prior use of psychedelics: None I felt like I was strapped to a Ferris wheel that wouldn’t stop spinning/falling really fast. As for me, I’ve found substantial relief for the first time ever (42 years of age). I hope this helps someone else.”, Spravato (esketamine) for Depression: “Details: a medium intranasal dose twice a week in office for a month, followed by a high dose once a week. Take the dose, relax and you absolutely want to be alone, lights off and listen to music YOU LIKE. THESE TWO COULD HAVE ABSOLUTELY NO RELATION TO EACH OTHER. Feeling like you’re completely numb. However, consciousness continued to be unbearably painful and a craving for self-annihilation became my default. I am going to try IV Ketamine infusions at some point, as I understand they are more effective for many reasons. One of the weirdest was the feeling of melting into the floor and then the floor dropping out. I have had no relief from my depression. Do not sit in a lighted room with the clinician. If you have a doctor giving you Spravato for severe anxiety- that’s insane! I think it is very promising but it is too new to have a history and I’m done being the guinea pig”, Spravato (esketamine): “I have Bipolar, untreatable depression, BPD. If you think this is just a way to get high your wrong. With the IV treatment, my symptoms fully resolved the night of treatment. I was also hospitalized 2 months later with pneumonia and fluid in my lower left lung. Overview; Side Effects; It was disappointing for me.”. Well last week I began running again and feel a bit of the depression lifting. I heard the ocean. Amazing experience, be prepared as well as you can ahead of time because it is intense. First two of 84mg were fine - trippy, slight visual disturbance but I was able to recognize that this was the drug and not me - felt like I smoked a ton of pot or something. I had to see someone else for one dosing and she left me in the room for 40 minutes by myself. No affect on my TRD (treatment resistant depression after 1 treatment. My clinician is great and believe me not all clinicians are all not that caring. Is Spravato (esketamine) a controlled substance? It was really scary. This is a new drug so they are still working on it.”, Spravato (esketamine): “I’ve finished my first 4 weeks of Spravato treatment at 2x per week. At no time have I had any “out-of-body” experiences; no dizziness; no side effects at all — other than mild sedation afterwards (for approximately 20-30 minutes). But I am dreading it more than I did with ECT.”, Spravato (esketamine): “I did the IV Ketamine for several months and found it very helpful, but it wore off very quickly. I believe that I may have better results with the 84mg and will be trying that dosage next week for week 2.”, Spravato (esketamine): “I began treatments with 56 mg which is four sprays using two syringes. I am trying to determine if these treatments are worth continuing. It's going to cost you $$. 84mg gives me some intense reactions. Currently available antidepressants target the monoamine neurotransmitter systems—predominantly serot… This has taken the suicidal thoughts and squashed it, My depression is very little I really don't like the treatment - feeling spaced out for 45 mins. It's more intense than the IV version and nowhere near as good as micro dosing mushrooms. Available for Android and iOS devices. It took 4 minutes to kick in. I hope this helps someone.”, Spravato (esketamine): “People need to understand that no one is the same and that EVERYONE will have different reactions. I started to feel sad again. I couldn’t hear my music anymore, that scared me. Sorry Janssen. The UK National Institute for Health and Care Excellence (NICE) has ruled that it will not recommend Spravato (esketamine) nasal spray for treatment-resistant depression within the National Health Service (NHS) because of concerns over efficacy and cost effectiveness.. Esketamine, in combination with a selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake … I had failed TMS and multiple oral medications so this new format of spraying something directly into your brain. After the first month of twice a week treatments and two additional weekly treatments, I stopped since I was convinced it was not helping my depression and was making me very anxious. The nasal spray dripping down your throat is horrible and I take zofran and omeprazole before my appointments to counter. Nothing you can choke on. I’ve yet to have an infusion. Experience: spray a mist of Spravato into each nostril while at the office. Does it last forever? While on it I had increased suicidal ideations. Not good when you're tripping out.”, Spravato (esketamine): “An update from September I've been on Spravato for over three months now and it seems to be helping although I'm still not seeing rainbows. I would be a poster child for this drug if I could.”, Spravato (esketamine): “Been on 84mg for over a year. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.
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